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K-means clustering of amplicon sequence variant data confirmed that 5-Amino-1MQ treatment generated a distinct cecal microbiome profile from all other treatment groups including diet-switched vehicle controls indicating that NNMT inhibition produces microbiome changes that are separable from those produced by dietary composition alone

This 43-amino acid peptide derives from thymosin beta-4, a naturally occurring protein that plays crucial roles in cellular organization and tissue repair

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