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Non-specific symptoms and signs are loss of appetite, diarrhoea, fatigue and weakness, shortness of breath, low blood pressure, confusion, and change in mental states.9 29 Classical manifestations include Hunters glossitis, megaloblastic anaemia, and subacute combined degeneration of spinal cord (Table 29)

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Answer: GLP-1 medications such as semaglutide and tirzepatide act on the GLP-1 pathway, while cagrilintide acts on the separate amylin pathway, which is why the two are additive rather than redundant when used together
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