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For competition experiments the cells were pre-treated with 1 M Carfilzomib, 1 M MLN4924 or 500 nM TAK243 for 1 h before the addition of SP3N or co-treated with different concentrations of SLF and SP3N

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4 Glutathione is also an anti-glycating agent, meaning it helps prevent the binding of sugar and protein molecules together, which is part of the natural aging process and also one of the main causes or contributing factors related to cataract formation