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These effects may result from an improved inflammatory status, inhibition of the muscle catabolic pathways and/or stimulation of the anabolic pathways

Cook, DG Repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunction Sci Transl Med 8 321: 321ra6
Inflammatory cytokines and chemokines as therapeutic targets in heart failure

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Some patients notice appetite changes within the first few weeks, while weight changes may occur more gradually