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CHAC1 is primarily regulated by the UPR pathway, specifically the PERK/eIF2/ATF4/ATF3/CHOP cascade, which is activated under conditions of ER stress

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ApoE4 carriers had lower lipid raft yield with greater membrane oxidation

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Front Mol Biosci 6:3 Krause D et al (2011) The tryptophan metabolite 3-hydroxyanthranilic acid plays anti-inflammatory and neuroprotective roles during inflammation: role of hemeoxygenase-1