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Rooibos has been consumed by locals for over 300 years, but it was not known outside South Africa until 1904 when Benjamin Ginsberg, a Russian immigrant to South Africa, recognized its potential and started trading with rooibos that he bought from the Khoi descendants and became the first exporter of rooibos

Another B-vitamin, vitamin B 2 , riboflavin, as a photosensitizing compound 359 , gives rise to the oxidative cleavage of folic acid and 5-methyl-THF by visible light, which is absorbed by and yields excited states of riboflavin 356,360,361

The peptides oral bioavailability is low (58%), but it accumulates preferentially in inflamed colonic tissue, making systemic absorption less critical

Indole-3-lactic acid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory in the immature intestine

The central role of glia may also explain the emerging recognition of mast cells in ME/CFS