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M., Bordey, A

Nitrosylation or glutathionylation of PDI leads to enzyme inactivation, activation of the unfolded protein response (UPR), and cancer cell death

136139 Consistent with these characteristics causing kidney damage through hypoxia, the db/db mouse shows increased glomerular expression of hypoxia-inducible factor 1 (HIF-1) and other genes involved in oxidative stress

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