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Considering the good response to the first multimodal treatment, we decided to schedule subsequent treatment cycles of oral and topical treatment for 24 months, using the same agents and doses and reducing the frequency of peri-plaque penile injections with pentoxifylline 100 mg to one penile injection every month for 12 months (second cycle) and subsequently, we further reduced the frequency of penile injections to one injection every 2 months for 12 months (third cycle)

Norris JD, Joseph JD, Sherk AB, Juzumiene D, Turnbull PS, Rafferty SW, et al

Rodgers, director del NIDDK, que explica la importancia de participar en los ensayos clnicos

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This approach is: More stable and shelf-friendly than isolated R-ALA Easier and more cost-effective to produce The form used in most clinical studies particularly those on diabetic neuropathy and metabolic support15 16 Some early research suggests R-ALA on its own may be more easily absorbed or better tolerated in sensitive individuals.17 18 Because R-ALA is more bioavailable, it spends less time in the stomach, moving more quickly into the intestines where absorption occurs