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50 M Ag alone exhibited no discernible impact on the activation status of JS-1, while 12.5, 50, 75 M Ag had significant inhibitory effects on the TGF-1-induced activation of JS-1

10.1158/2159-8290.CD-19-0959 152 PatriarcaE

Given the dismal prognosis of PC treatment is hindered by a dense desmoplastic stroma, profound hypoxia, limited T-cell infiltration, and abundant immunosuppressive myeloid populations, together forming physical and immunological barriers to effective therapy

One of the most significant downstream effects of this activation is the upregulation of mTOR , a master regulator of protein synthesis

[DOI] [PMC free article] [PubMed] [Google Scholar] 647.Kim J.K., Gimeno R.E., Higashimori T., Kim H.J., Choi H., Punreddy S., Mozell R.L., Tan G., Stricker-Krongrad A., Hirsch D.J., et al