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Additionally, several synthesized structural analogs have shown potential as TMAO biosynthesis inhibitors

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In cholesterol-fed mice, knockdown of FMO3 induced macrophage RCT stimulated by liver X receptor (LXR), thus improving the cholesterol balance and protecting against AS (Warrier et al., 2015)

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After treated with L-carnitine, serum levels of IL-1, IL-6 and TNF-, and the skeletal muscle content of MuRF1, MaFbx, FOXO3, p-FOXO3a, Akt, p-Akt, p70S6K and p-p70S6K were measured