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doi: 10.1007/s00535-012-0653-5
This causes a rapid shift in cellular physiology, and the cells progress through mitosis as efficiently as possible

However, there is one caveat
This timing aligns peak peptide receptor occupancy (which occurs 90180 minutes post-injection) with the UV-induced DNA damage signal that activates tyrosinase, the rate-limiting enzyme in eumelanin synthesis

This is not caused directly by the medication but by rapid weight loss and caloric restriction
