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doi: 10.1007/s00535-012-0653-5

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This causes a rapid shift in cellular physiology, and the cells progress through mitosis as efficiently as possible

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However, there is one caveat

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This timing aligns peak peptide receptor occupancy (which occurs 90180 minutes post-injection) with the UV-induced DNA damage signal that activates tyrosinase, the rate-limiting enzyme in eumelanin synthesis

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This is not caused directly by the medication but by rapid weight loss and caloric restriction

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