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Gastrointestinal symptoms including nausea, vomiting, diarrhea, or abdominal cramping may indicate dose-related intolerance or individual sensitivity

Results: We identified 3809 records with 17 randomized trials selected for analysis (Figure 1)

Fraser et al, however, reported no resistance by patients to reducing the frequency of their injections

Statistical analysis was performed on SPSS 17 (Statistical Package for Social Sciences, USA)

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