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Recent findings have identified a delayed form of cardiotoxicity in childhood cancer survivors, occurring up to 15 years after treatment, highlighting the need for long-term monitoring (Figs

CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC)

For each patient, biochemical analysis of fibrillar (pro)collagen chains was performed at least twice as described previously

For in vivo studies, the number of animals used must be kept to an absolute minimum [472]

Because it contains no therapeutic drug, it functions only as a preparation solution