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More precisely, they found a higher risk in testicular cancer in men who reported using more than one kind of supplement, in those who started using supplements before the age of 25, and in those who used supplements for three years or more

10.1002/brb3.558 27 BanksW

Ealy 2011

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Since Complex I and III are often heralded as the chief sites of mitochondrial ROS production, other sites including 2-oxoglutarate dehydrogenase (Odh), branched chain amino acid dehydrogenase (Bckdh), pyruvate dehydrogenase (Pdh), Sdh, dihydroorotate dehydrogenase, FAD-linked glycerol-3-phosphate dehydrogenase, proline dehydrogenase, and electron transfer flavoprotein ubiquinone:oxidoreductase are often overlooked (Murphy, 2012a)