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However, it should be emphasized that the generalizability of our findings targeting PEX5, which undermines peroxisome biogenesis and integrity, may be limited in diseases with intact peroxisome biogenesis, including adrenoleukodystrophy, in which PEX5 expression and function are conserved and in which pathogenic mechanisms stem from disruptions in specific peroxisomal pathways rather than global peroxisome dysfunction

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[48] The downplaying of community action by the Times , however unintentional, may have created a self-fulfilling lack of urgency, for neither that newspaper nor any other major newspaper or television station outside of Michigan would return to or visit the story for another half year