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It is commonly used as a supplement for people suffering from pernicious anemia

In medical weight loss, commonly used peptide classes include growth-hormonerelated peptides (like AOD9604 or tesamorelin), appetite- and glucose-regulating agents (such as GLP1 analogs), and others that influence insulin sensitivity, inflammation, and body composition

When to Choose AOD-9604: AOD-9604 is particularly well-suited for individuals seeking selective fat metabolism enhancement without broader hormonal changes, those who have not responded adequately to diet and exercise alone for stubborn fat reduction, individuals who cannot tolerate or are contraindicated for GLP-1 agonists or growth hormone, athletes needing body composition improvement without affecting glucose regulation or hormone levels, and those preferring a well-researched peptide with established safety data from clinical trials

Nuclear NAD + is generated by nuclear NMNAT1 and is largely utilized by PARPs for DNA damage response and nuclear sirtuins such as SIRT1, SIRT6 or SIRT7 for epigenetic deacetylation 82,86

Contraindications Given the limited safety data, conservative contraindications would include pregnancy or plans to become pregnant, breastfeeding, age under 18, severe liver or kidney disease, and any condition requiring medications with unknown interaction potential