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It also complements vitamin E, which helps reduce the oxidation of unsaturated fatty acids, supports the integrity of cell membranes, promotes the health of skin and blood cells, and helps lower free radical formation with its antioxidant effects

Therefore, ascleposide exerts indirect and direct effects on cell cycle regulation, and decreases the G1 distribution of cells while increasing the proportion of cells in G2/M and sub-G1 phase 150

According to literature, many other natural products like glycoside components need to be metabolized and deglycosylated by the intestinal flora to exert better pharmacological activity ( To further elucidate the mechanism of poor bioavailability and seek solutions, combined administrations with vegetable oil, urea, metronidazole, and verapamil were attempted to improve lipid solubility, intestinal permeability and inhibit intestinal microbiota and P-gp

"The relief I felt after arthrocentesis was amazing," shares one of our patients