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Beyond energy conversion, mitochondria are indispensable for a myriad of other cellular processes, including heme and steroid hormone synthesis, calcium ion (Ca 2+ ) buffering to regulate intracellular signaling, and the initiation of apoptosis via the mitochondrial pathway (36)

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Muscle loss is a significant practical concern, with studies showing that 30-40% of weight lost on GLP-1 agonists can be lean mass if protein intake and resistance training are neglected

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