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Then, ATP depletion leads to the failure of energy-dependent ion pumps (e.g., Na + /K + -ATPase), resulting in ionic imbalances, including the influx of calcium (Ca 2+ ), sodium (Na + ), and chloride (Cl ) ions into the cell, and the efflux of potassium (K + ) [23]

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Discussion Metabolic derangement accompanying influenza infection has been increasingly recognized as having an important role in the pathogenesis of virus-induced lung injury