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Non-specific symptoms and signs are loss of appetite, diarrhoea, fatigue and weakness, shortness of breath, low blood pressure, confusion, and change in mental states.9 29 Classical manifestations include Hunters glossitis, megaloblastic anaemia, and subacute combined degeneration of spinal cord (Table 29)

The KD is contraindicated in AP because the pancreas plays a key role in fat digestion by synthesising enzymes such as lipase, phospholipase and esterase [121,122]

The first signs of B12 deficiency include persistent fatigue, weakness, lightheadedness, pale skin, tingling or numbness in the hands and feet, difficulty concentrating, and mood changes like irritability or mild depression

Bynke et al., 2020), is heavily expressed in the dorsal vagal complex of the brainstem, and its stimulation on astrocytes has been related to the regulation of learning and memory (Poulin et al., 2010)

To account for autofluorescence, the MFI of the region of interest was corrected by subtracting the MFI of four background regions within the same image