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What is sensed by ASJ and/or IL2, and why these upstream signals regulate, is unknown to us, and it will be very interesting to study them in the future

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It is essential to start with a lower dose and gradually titrate up to assess tolerance, particularly for patients with severe ME/CFS who may be highly sensitive to metabolic shifts

Special attention is paid to the upregulation of hypoxia inducing factor-1 and the subsequent stimulation of the genes coding for glucose transporter-1 (GLUT-1) and the growth factors transforming growth factor- (TGF), vascular endothelial growth factor (VEGF), plasminogen growth factor activator inhibitor-1 (PAI-1) and connective tissue growth factor (CTGF)

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