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A similar theoretical concern was raised about human growth hormone therapy more than 40 years ago

Pharmacokinetics in patients with impaired renal function study design, data analysis, and impact on dosing

this occurs because there is not enough vitamin B12 in the diet or poor absorption Pernicious anemiaa type of megaloblastic anemia caused by a lack of intrinsic factor so that vitamin B12 is not absorbed Fatigue, weakness Nerve damage with numbness, tingling in the hands and legs Memory loss, confusion Dementia Depression Seizures Toxicity Toxicity Vitamin B12 is a water-soluble vitamin, so any unused amount will exit the body through the urine

Kang-Lee, Y

The volume of work is moderate, not large