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Clinical Significance of Folate Deficiency Folate deficiency results in complications nearly identical to those described for vitamin B12 deficiency

As also mentioned above, glyceraldehyde-3-phosphate can also re-enter the pentose phosphate pathway by reacting with fructose-6-phosphate via transaldolase or transketolase enzymes

& Tabas, I

Stimulation of the hydrolytic activity and decrease of the transpeptidase activity of -glutamyl transpeptidase by maleate

Furthermore, a chronic inflammatory state in the nervous system intensifies with age, leading to increased microglial activation and elevated levels of proinflammatory cytokines, such as tumor necrosis factoralpha (TNF) and interleukin1 beta (IL1), detectable even preclinically [63, 64]