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In the head-to-head SURMOUNT-5 trial (NEJM, 2025), tirzepatide produced 20.2% body weight loss vs 13.7% for semaglutide at 72 weeks, with similar side-effect profiles

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Wu, Y., Yu, S

Kondo et al., 2018)

Given the absence of human trials, the regulatory status, the quality concerns with research peptide vendors, and the cancer biology questions around c-Met activation, the case for Dihexa is weak