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Both RickA and Sca2 contribute to cell-to-cell spread, however Sca2-based motility is the major mediator of cell-to-cell spread 34,35,36,37,64

Iron plays a crucial role in the synthesis of neurotransmitters in the brain such as DA, epinephrine, norepinephrine and serotonine, and in the production of ATP in the mitochondria through the process of electron transport in an organ like the brain that requires a considerable amount of energy

Although controversy remains over whether KD should be used to treat cancer, therapies that slow or stop cancer growth in early stages, use a broad-spectrum approach, target many signaling pathways, prevent cancer comorbidities such as cachexia and obesity, and have fewer adverse effects are very appealing