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The regulation of B cell lymphoma extra-large deamidation has a critical role in the tumour-specific activity of DNA-damaging antineoplastic agents 29,30 , suggesting that deamidation might also be a functional PTM affecting the DDR

Zinc is necessary for the activity of a number of transcription factors such as those of the nuclear receptor (steroid and thyroid hormone receptor superfamily) family through its role in the formation of the structurally critical zinc finger domain that binds to DNA

Lam M, Pereira AAL, Marie PK, Davis JS, Yu RX, Morris J, Manyam GC, Broom BM, Maru DM, Katkhuda R, Menter D, Kopetz S

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