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LippmanSMKleinEAGoodmanPJLuciaMSThompsonIMFordLGet al

Next, all the final energies were obtained from single point energy calculations at B3LYP/6-31 G** level with the PBF continuum solvation model for water implemented in QSite

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10.1002/prca.201400130 193

Signaling pathways from Trk activation: PI3K/Akt pathway phosphorylates Bad (pro-apoptotic protein) preventing it from blocking Bcl-2 and Bcl-xL (anti-apoptotic proteins)
