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There were several limitations of this study

Indeed, we observed a significantly increased level of glutathione sulfinamide in the redox reaction system involving glutathione and Angelis salt (HNO source) (Supplementary Fig

We found that RNAi of Chop mRNA significantly attenuated Mgst2 mRNA expression under ER stress, placing Mgst2 transcriptional induction at the late, death-promoting phase of the UPR and downstream of CHOP (Supplementary Fig

Princeton, NJ: Integrated Care Resource Center

Future clinical trials specifically designed to evaluate this combination will be essential in determining its safety profile and optimal use