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Activation of mTORC1 signaling has been found to inhibit the interaction between lysosomal NPC1 and mitochondrial translocator protein (TSPO), resulting in the untethering of mitochondria-lysosome contact sites and cholesterol accumulation, indicating that mTORC1 serves as a central component of lysosomal signaling, mediating cholesterol trafficking from lysosomes to mitochondria by modulating the interaction between NPC1 and TSPO (Lin et al., 2023)

doi: 10.1080/10408398.2021.2007844 19

JAMA - J Am Med Assoc 316:13921401

They participate in neutralizing reactive oxygen species [22, 23], thereby reducing oxidative stress and inflammation in the intestines

Additionally, glycine is an agonist for glycine-gated chloride channels that are expressed by a range of tissues peripherally and in the central nervous system.24-28 Activation of glycine-gated chloride channels has a depolarizing impact on cells that actively accumulate chloride and a hyperpolarizing impact on those that do not