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R(+)--lipoic acid is generally recognized to exhibit superior activity compared to S(-)--lipoic acid [2,3,4,5,6], even as -lipoic acid is usually marketed as a racemic mixture containing both enantiomers

After 18 weeks, the authors discovered that the antioxidants in the fruit turned on antioxidant defense pathways, which ultimately increased the activity of genes that boost the production of glutathione

Moreira-Pinto B, Costa L, Felgueira E, Fonseca BM, Rebelo I

doi: 10.1097/01.CCM.0000278913.19123.13

Key considerations if a patient discloses combined use include: Gastrointestinal effects : Both agents may independently cause nausea, vomiting, or appetite suppression