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It is naturally produced in nearly every cell of the body and plays a central role in: Neutralizing free radicals that cause oxidative stress and cellular damage Supporting liver detoxification , particularly in Phase II detox pathways Regulating the immune system , helping balance inflammation and defense Repairing DNA and proteins , essential for anti-aging and longevity Because of its central role in cellular defense, glutathione is often called the master antioxidant. However, levels can drop due to aging, chronic stress, poor diet, toxin exposure, or genetic variants like MTHFR , which can limit glutathione recycling

Oral supplements are most convenient, but IV administration is considered the most effective for rapid and significant increases in blood levels

Geographical distribution of MTHFR C677T, A1298C and MTRR A66G gene polymorphisms in China: findings from 15357 adults of Han nationality

Bi G, Liang J, Bian Y, Shan G, Huang Y, Lu T, et al

Driven by microvascular damage, inflammation, oxidative stress, and advanced glycation end products, DR progresses differently in T1DM (rapid onset) and T2DM (chronic inflammation)