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MOTS-c's AMPK activation increases NAD+-dependent processes immediately, but 5-Amino-1MQ's NNMT inhibition takes 90120 minutes to elevate intracellular NAD+ meaningfully

If you dosed 5-Amino-1MQ at 8am and it's now 3pm (7 hours), taking MOTS-c still provides some benefit but misses peak NNMT inhibition

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Elie Metchnikoff, the discoverer of the macrophage, was the first to observe the increased abundance of macrophages in ageing tissues more than 100 years ago