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A key oxidative effect is lipid peroxidation via enhanced activity of acylCoA synthetase longchain family member 4 (ACSL4), arachidonate lipoxygenase (ALOX) and its prolyl hydroxylase domain for the production of activated polyunsaturated fatty acid coenzyme A (PUFA-CoA) and phospholipid PUFA proxides in the presence of excess ROS (Chen et al

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doi: 10.1016/j.intimp.2006.08.015 173 ChakravorttyDKoideNKatoYSugiyamaTMuMMYoshidaTet al

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