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doi: 10.1023/a:1005507913372

As a core metabolic product, lactate may promote the release of inflammatory mediators (e.g., IL-6, TNF-) by activating the TGF- signaling pathway, while enhancing NF-B pathway activity to exacerbate local inflammatory infiltration in lung tissue but this direct activation has not been demonstrated in COPD airway cells
Austin DW, Shandley K (2008) An investigation of porphyrinuria in Australian children with autism

doi: 10.1038/nature11551 46 LozuponeCAStombaughJIGordonJIJanssonJKKnightR

methylene tetrahydrofolate reductase, SHMT
