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This, in turn, further exacerbates the accumulation of A and tau, ultimately leading to impaired synaptic plasticity and cognitive impairment ( A number of studies have demonstrated that there are extensive mitochondrial abnormalities in the brains of AD patients and animal models (Swerdlow, 2018)

Mol Asp Med 30:112 Gallant KR, Cherian MG (1989) Metabolic changes in glutathione and metallothionein in newborn rat liver
