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In research settings, combining two reconstituted peptides into a single nasal spray bottle is sometimes done when the compounds are compatible in solution

doi: 10.1038/nrc3844 77 GreeneCJAttwoodKSharmaNJBaldermanBDengRMuhitchJBet al

As you can imagine, trying to steer a derailed train back onto the train tracks is a difficult task-- the collagen fibrils in the tendon simply struggle to self-organize and grab hold of each other for cross-linking like they normally should, hence the tendon is not able to rebuild and restrengthen itself

[DOI] [PubMed] [Google Scholar] Oommen AM, Griffin JB, Sarath G, Zempleni J

10.1155/2019/9212314 157 ZhangN.XueL.YounasA.LiuF.SunJ.DongZ.et al (2022a)
