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and Moorthy B., Role of Cytochrome P450s in the Generation and Metabolism of Reactive Oxygen Species, Current Opinion in Toxicology 7 (2018): 4451

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And your liver gets overloaded and damaged, making it unable to do its job of detoxification
Jha N., Kumar M
Metabolic disorders including high sugar level, excessive body fat on waist, and high cholesterol levels are some of the common issues in people having acanthosis nigricans