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This response appears to be attenuated by L-carnitine supplementation which reduces intracellular hypoxanthine and xanthine oxidase following resistance exercise bouts [109] whereas other experimental investigations failed to demonstrate such effect [116, 117]

However, neuropsychiatric symptoms developing on the basis of direct brain tissue pathology or underlying vascular dysfunction are considered to be a major and the most common feature of long COVID [4, 7, 31, 37, 65, 88, 113], with potentially devastating consequences for affected individuals

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Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013

These findings highlight the gut-brain axis as a significant factor in the pathogenesis of anti-NMDAR encephalitis and suggest new therapeutic approaches