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Effects of hyperand hypothyroidism on the development and proliferation of testicular cells in prepubertal rats

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The first involves the aberrant activation of SHP-1, resulting in reduced activation of MAP kinase signaling upstream of p47 phox phosphorylation, and the second involves the activation of Epac (the exchange protein directly activated by cAMP), which promotes inhibition of PLC through an unknown mechanism (Cerny et al., 2017)

Metformin alleviates endometriosis and potentiates endometrial Receptivity via decreasing VEGF and MMP9 and increasing leukemia inhibitor factor and HOXA10