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Surprisingly, our attempts to demonstrate a direct interaction between bacterial-purified GST-CDK4, GST-CDK6, and His-YAP1 in vitro did not yield detectable results, nor could we observe the phosphorylation of YAP1 using a CDK-substrate specific antibody (Fig

Bellomo F, De Leo E, Taranta A, Giaquinto L, Di Giovamberardino G, Montefusco S, Rega LR, Pastore A, Medina DL, Di Bernardo D, De Matteis MA, Emma F (2021) Drug repurposing in rare diseases: an integrative study of drug screening and transcriptomic analysis in nephropathic cystinosis

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Having said that, concerns initially raised about the current LNP formulations due to the need for more clarity about the potential direct or indirect toxic or immune adverse effects on mothers and fetuses