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Cholesterol in the central nervous system (CNS) comes, almost entirely, from endogenous synthesis as the circulating cholesterol is unable to cross the bloodbrain barrier (BBB)

The "Cu" is copper's chemical symbol

Using the unpaired genes as queries, we searched the homoeologs within the syntenic block of the counterpart subgenome to check for gene deletion

These findings indicate that, under AD conditions, astrocytes and neurons exhibit distinct autophagic responses