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This study explores a novel metabolism-based therapeutic approach using a polyurea generation 4 dendrimer (PURE G4 ) surface functionalized with lactate (LA) (PURE G4 -LA 24 ), to take advantage of glucose-dependent monocarboxylate transporters (MCTs) overexpression, loaded with selenium-chrysin (SeChry) and temozolomide (TMZ) or complexed with anti-glutaminase ( GLS1 ) siRNAs to abrogate glutamine dependence

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Why Its Relevant to Weight Loss and Diabetes
