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Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance

The ubiquitin with G76V mutation was fused to residues 8121 of uS10, lacking two lysine residues for ubiquitination (Fig

GSSG generated in these processes can be either recycled to GSH by a NADPH-dependent reaction, catalyzed by GR 3 , or pumped out of the cell by ATP-dependent processes, with multidrug resistance-associated protein-1 (MRP-1) being the major pathway for GSSG efflux 33

The rich antioxidant substances in plants have been shown to play a role in delaying aging, and in recent years, significant research has focused on also examining their potential role in AD onset and progression

Evolutionally, CYCS has been found to induce ROS-independent and cardiolipin-specific lipid peroxidation based on its redox state, indicating its specific role in lipid peroxidation [218]