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Generally speaking, Nrf2 pathway is an important antioxidant stress pathway found in vivo at present

sodium nitrite (NaNO2) as well as the role of the garlic oil in amelioration of the neurotoxicity in male albino rats

More importantly, chronic morphine exposure induces oxidative stress via -opioid receptors/phospholipase D2/NADPH oxidase and -opioid receptors/nitric oxide synthase pathway, which is associated with morphine tolerance, dependence, and addiction

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