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The parental cell lines showed an increase in 5-methyl-THF production in response to Hcy treatment, while the knockin cell lines had high basal levels of 5-methyl-THF and did not respond to Hcy treatment

10.1089/ars.2011.4255 Antioxid

[PubMed: 11133160] 80
Gillman, 2007)
0.5, 5, 50 g/mL) in ICR mice is the only reviewed study providing clear histological evidence of cardiotoxicity, which proved to be dose-dependent and prominent at 50 g/mL