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The recently updated Life's Essential 8 (LE8) metrics, outlined by the American Heart Association (AHA), have demonstrated significant benefits in reducing cardiovascular disease risk and promoting overall cardiovascular health (38)

Chronic oxidative stress as a mechanism for glucose toxicity of the Beta cell in type 2 diabetes

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they recruit cAMP response element-binding protein (CREB)-binding protein (CBP) or receptor-associated coactivator 3 (RAC3), to facilitate the transactivation of NRF2 target genes [146, 147]

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