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While the mechanistic data for how LDN and these specific peptides work is strong and growing, large-scale, double-blind clinical trials for their combined use in Hashimotos are still lacking

The control group received TENS plus lidocaine injection

Some improvements in insulin sensitivity and inflammatory markers can begin emerging within 4 to 8 weeks of treatment Leptin normalization, however, follows actual fat mass reduction rather than drug exposure directly, meaning those benefits likely take months of sustained treatment

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