how does glutathione enter the cell Extracellular is unable to cross membrane as it is Frontiers | Glutathione and mitochondria
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A Functional Transsulfuration Pathway in the Brain Links to Glutathione Homeostasis

Selected References (PubMed/PMC) Pickart et al

Immunosuppressants, such as interferon- or hydroxyurea, for severe forms of HES

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Cells can stave off ferroptotic fate through the use of antioxidant pathways that largely utilize GSH, glutathione peroxidase 4 (GPX4), and perioredoxin-thioredoxin, which all ultimately rely on NADPH for regeneration