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Remodeling and resorption of bone is a key feature of primary bone malignancies like OS and ES, leading to an osteolytic bone environment that provides space for growth of the tumor (106, 107).The metabolic crosstalk in and among these cell types, and how it influences and is influenced by tumor cells, are important outstanding questions that are beginning to be addressed

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11 (2010): 32323242, 10.1093/brain/awq200

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As can be seen from the available literature, a large number of studies using oxygen-glucose deprivation and reperfusion (OGD/R) cell cultures, as well as laboratory animal models of experimental brain ischemia mimicking conditions of ischemic injury, have demonstrated the potential benefit of neuroprotection