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In gastric cancer cells, MR activates BNIP3 gene expression by downregulating lncRNA PVT1 expression and interacting with DNMT3, thereby activating mitophagy and inducing cell death ( In summary, methionine restriction selectively exacerbates the oxidative stress in cancer cells by targeting their antioxidant metabolic vulnerability-particularly through disrupting glutathione synthesis-thereby ultimately inducing cell death

[DOI] [PubMed] [Google Scholar] 38.Izzo LT, Trefely S, Demetriadou C, Drummond JM, Mizukami T, Kuprasertkul N, et al

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